Potency (pharmacology)

– Types of Potency:
– Effective dose (ED50): Minimum dose/concentration producing response in 50% of population
– Median lethal dose (LD50): Minimum dose causing death in 50% of cases
– Median toxic dose (TD50): Minimum dose causing toxicity in 50% of cases
– Half maximal effective concentration (EC50): Concentration inducing 50% of maximum response
– Half maximal inhibitory concentration (IC50): Measure of substance potency in inhibiting function

– International Union of Basic and Clinical Pharmacology (IUPHAR):
– Defines potency as imprecise and needing further clarification
– Lists types of potency like ED50, LD50, TD50, EC50, IC50
– Emphasizes importance of defining potency accurately
– Provides guidelines for understanding potency in pharmacology
– Aims to standardize terminologies in pharmacology

– Potency vs. Effectiveness:
– Potency measures dose required for specific effect intensity
– Highly potent drugs need lower concentrations for response
– Potency doesn’t equate to effectiveness or side effects
– Effectiveness refers to overall impact of drug on desired outcome
– Balance between potency and effectiveness crucial in drug development

– Potency Measurement:
– Concentration-response curves depict potency concept
– Drug potency shown by response at different concentrations
– Potency determines drug’s biological activity
– Potent drugs evoke response at low concentrations
– Lower potency drugs require higher concentrations for same response

– Importance of Potency in Pharmacology:
– Potency crucial in determining drug dosage
– Helps understand drug’s efficacy and safety profile
– Potency influences drug’s therapeutic utility
– Potency impacts drug development and clinical use
– Pharmacologists use potency to compare and evaluate drug effects

Potency (pharmacology) (Wikipedia)

For other uses, see Potency (disambiguation).

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In pharmacology, potency or biological potency is a measure of a drug's biological activity expressed in terms of the dose required to produce a pharmacological effect of given intensity. A highly potent drug (e.g., fentanyl, clonazepam, risperidone, benperidol, bumetanide) evokes a given response at low concentrations, while a drug of lower potency (e.g. morphine, alprazolam, ziprasidone, haloperidol, furosemide) evokes the same response only at higher concentrations. Higher potency does not necessarily mean greater effectiveness or more side effects.